杨力
杨力，1998年7月本科毕业于兰州大学，2004年3月于中科院中国科学院上海生命科学研究院生物化学与细胞生物学研究所获博士学位。
现任复旦大学生物医学研究院研究员。
个人资料
杨力于1998年本科毕业于兰州大学生物化学与分子生物学专业。毕业后前往中国科学院生物化学与细胞生物学研究所攻读博士学位。2004年博士毕业后师从于1989年诺贝尔化学奖SidneyAltman，在耶鲁大学进行博士后工作。2007年在康涅狄格大学Brenton R. Graveley实验室继续博士后工作。
2010年10月，杨力回国，获任中国科学院上海生命科学研究院科研处处长，次年7月任中科院-德国马普学会计算生物学伙伴研究所/上海营养与健康研究所研究员。
2022年2月起任复旦大学生物医学研究院研究员。
工作经历
08/2011-date: Principle Investigator, Professor, Chinese Academy of Sciences - Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
10/2010-07/2011: Director, Professor, Department of Scientific Research Management, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
01/2007-09/2010: Postdoctoral Fellow with Dr. Brenton R. Graveley, University of Connecticut Health Center, Farmington, CT 06030, USA.
08/2004-12/2006: Postdoctoral Associate with Dr. Sidney Altman (Nobel Laureate in 化学, 1989), 耶鲁大学 University, New Haven, CT 06520, 南阿拉巴马大学
09/1998-07/2004: Ph.D. student and research assistant with Dr. Bo-Liang Li, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
研究方向
从1990年开始到2001年第一个人类全基因组测序结果发表，人类基因组计划仅耗材花费就高达30亿美元。利用新一代高通量测序技术，基因组测序的时间和耗费被极大地降低了，这使得高通量测序技术被广泛的应用于生命科学研究的各个领域中，极大的促进了现代生命科学的发展。杨力实验室利用高通量测序技术和相应的计算生物学分析方法，对真核生物核糖核酸的表达调控在全转录组水平进行系统检测，主要围绕模式生物果蝇和人源胚胎干细胞及其定向分化的RNA选择性剪接和非编码RNA功能作用进行研究，并系统解析RNA的复杂调控网络。实验室将利用实验（包括新一代高通量测序，分子和细胞生物学等）和计算（包括统计，生物信息学等）生物学的方法进行系统研究，以期拓展人类在全转录组水平对RNA重要生理功能及其调控作用的全面认识。
代表性论文
2015:
Angela N Brooks*, Michael O Duff, Gemma May, Li Yang, Mohan Bolisetty, Jane Landolin, Ken Wan, Jeremy Sandler, Susan E Celniker, Brenton R Graveley# and Steven E Brenner#. Genome Res 2015, doi: 10.1101/gr.192518.115
Jian-Feng Xiang, Li Yang, Ling-Ling Chen#. The long noncoding 核糖核酸 regulation at the MYC locus. Curr Opin Genet Dev 2015, 33:41–48
Cuiqing Zhong*, Qi Yin*, Zhenfei Xie*, Meizhu Bai*, Rui 越南盾*, Wei Tang, Yu-Hang Xing, Hongling Zhang, Suming Yang, Ling-Ling Chen, Marisa S. Bartolomei, Anne Ferguson-Smith, Dangsheng Li, Li Yang#, Yuxuan Wu# and Jinsong Li#. CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide 核糖核酸 Library. Cell Stem Cell, 2015, 17: 1-12
Chen LL# and Yang L#. Gear up in circles. 摩尔 Cell, 2015, 58:715-717 (Preview)
Hu SB, Xiang JF, Li X, Xu Y, Xue W, Huang M, Wong CC, Sagum CA, Bedford MT, Yang L, Cheng D, and Chen LL. Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus. Genes \u0026 Dev, 2015, 29: 630-645
Ling-Ling Chen# and Li Yang#. Regulation of circRNA biogenesis. RNA Biology, 2015, 12: 381-388
Chen T*, Xiang JF*, Zhu S*, Chen S, Yin QF, Zhang XO, Zhang J, Feng H, 越南盾 R, Li XJ, Yang L# and Chen LL#. 2015. ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner. Cell Res, 2015, 25: 459-476
Yin QF*, Hu SB*, Xu YF, Yang L, Carmichael GG and Chen LL. SnoVectors for nuclear expression of 核糖核酸 Nucleic Acids Res, 2015, 43: e5
Wang D*, Cai C*, Dong X, Yu QC, Zhang XO, Yang L, Zeng YA. Identification of multipotent mammary stem cells by protein C receptor expression. Nature, 2015, 517:81-84
Yin QF, Chen LL# and Yang L#. Fractionation of Non-polyadenylated and Ribosomal-free RNAs from Mammalian Cells. Methods 摩尔 Biol, 2015, 1206: 69-80 (Book chapter)
2014:
Yang L# and 金钟大 LL#. Microexons go big. Cell, 2014, 159: 1488-1489 (Invited preview)
Yang L# and Chen LL#. Competition of 核糖核酸 splicing: line in or circle up. Sci China Life Sci, 2014, 57: 1232-1233 (Invited review)
Dong R, Chen LL and Yang L. Research progress of circular RNA in the post-genome era. Chinese J Cell Biol, 2014, 36: 1455-1459 (Invited review, in Chinese)
Zhang XO*, Wang HB*, Zhang Y, Lu X, Chen LL# and Yang L#. Complementary sequence-mediated exon circularization. Cell, 2014, 159: 134-147 (Issue Highlight)
Editorial by: Vicens Q and Westhof E. Cell, 2014, 159: 13-14
Highlighed by: Nat Rev Genet, 2014, 15: 707
Gerstein M*, Rozowsky J*, Yan KK*, Wang D*, Cheng C*, 褐色 JB*, Davis C*, Hillier L*, Sisu C*, Li JJ*, Pei B*, Harmanci AO*, Duff MO*, Djebali S*, Alexander RP, Alver BH, Auerbach R, Bell K, Bickel PJ, Boech ME, Boley NP, Booth BW, Cherbas L, Cherbas P, Di C, Dobin A, Drenkow J, Ewing B, Fang G, Fastuca M, Feingold EA, Frankish A, Gao G, Good PJ, Guigo R, Hammonds A, Harrow J, Hoskins RA, Howald C, Hu L, Huang H, Hubbard TJP, Huynh C, Jha S, Kasper D, Kato M, Kaufman TC, Kitchen RR, Ladewig E, Lagarde J, Lai E, Leng J, Lu Z, MacCoss M, May G, McWhirter R, Merrihew G, Miller DM, Mortazavi A, Murad R, oliver B, Olson S, Park PJ, Pazin MJ, Perrimon N, Pervouchine D, Reinke V, Reymond A, Robinson G, Samsonova A, Saunders G, Schlesinger F, Sethi A, Slack FJ, Spencer WC, Stoiber MH, Strasbourger P, Tanzer A, Thompson OA, Wan KH, Wang G, Wang H, Watkins KL, Wen J, Wen K, Xue C, Yang L, Yip K, Zaleski C, Zhang Y, Zheng H, Brenner SE#, Graveley BR#, Celniker SE#, Gingeras TR# and Waterston R#. Comparative analysis of the transcriptome across distant 物种 Nature, 2014, 512: 445-448
Zhang Y, Yang L and Chen LL. Life without A tail: new formats of long noncoding RNAs. Int J Biochem and Cell Biol, 2014, 54: 338-349 (Invited review)
Zhang XO, Yin QF, Chen LL and Yang L. Gene expression profiling of non-polyadenylated 核糖核酸-seq across 物种 Genomics Data, 2014, 2:237-241
Zhang XO*, Yin QF*, Wang HB, Zhang Y, Chen T, Zheng P, Lu X, Chen LL# and Yang L#. Species-specific alternative splicing leads to unique expression of sno-lncRNAs. BMC Genomics, 2014, 15: 287 (Highly Accessed)
Editorial by: BioMed Central portal-Biome on 17th April 2014: sno-lncRNAs: a story of splicing across humans, rhesus and mice (http://www.biomedcentral.com/biome/sno-lncrnas-a-story-of-splicing-across humans-rhesus-and-mice/)
Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO,Wu Z, Zhang S, Wang HB, Ge JH, Lu XH, Yang L and Chen LL. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions in the MYC locus. Cell Res, 2014, 24:513-531 (Cover Article and Issue Highlight)
Editorial by: Younger ST and Rinn JL. Cell Res, 2014, 48:155-157
Highlighted by: Nature.com
Highlighted by: Global Medical Discovery
Highlighted by: National Science Reviews
2013:
Zhang Y*, Zhang XO*, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L# and Chen LL#. Circular intronic long noncoding RNAs. 摩尔 Cell, 2013, 51: 792-806 (Issue Highlight)
Editorial by: Bolisetty MT and Graveley BR. Mol Cell, 2013, 51:705-706
Editorial by: Reid T. Nature China, 2013, Epub. on Oct. 2nd (doi:10.1038)
Editorial by: Tomkins J. Institute for Creation Res, 2013, Epub. on Oct. 9th
Research Highlight by: Nature, 2013, 501:464
Zhu S*, Xiang JF*, Tian C, Chen LL# and Yang L#. Prediction of constitutive A-to-I editing sites from human transcriptomes in the absence of genomic sequences. BMC Genomics, 2013,14: 206 (Highly Accessed)
Zhu S, Zhang XO and Yang L. Panning for long noncoding RNAs. Biomolecules, 2013, 3: 226-241 (Invited review)
Yang L, Wei G, Tang K, Nardini C and Han JD. Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures. Sci China Life Sci, 2013, 56: 213-219 (Invited review)
2012:
Bass B, Hundley H, Li JB, Peng Z, Pickrell J, Xiao XG and Yang L. The difficult calls in RNA editing. Nat Biotechnol, 2012, 30: 1207-1209 (Invited review)
Yin QF*, Yang L*, Zhang Y, Xiang JF, Wu YW, Carmichael GG# and Chen LL#. Long noncoding RNAs with snoRNA ends. 摩尔 Cell, 2012, 48: 219-230 (Cover Article and Issue Highlight)
Editorial by: McCann KL and Baserga SJ. Mol Cell, 2013, 48:155-157
Editorial by: David R. Nat Rev Mol Cell Biol, 2012, 13:686
News coverage by: Foundation for Prader-Willi Research
Recommended by: 5 articles in F1000 Prime
Best of Molecular Cell 2012
参考资料
中科院“杰青”杨力已加盟复旦大学生物医学研究院.澎湃新闻.2022-02-14
Publications.Eukaryotic Transcriptomics (Yang Lab).2015-08-26