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  2. 冯亚凯

冯亚凯

冯亚凯,男,1966年12月出生,天津大学化工学院教授,博导。

天津市化工学会委员,天津市生物医学工程学会委员

Polymers for Advanced Technologies, Journal of Cellular Biotechnology, International Journal of Polymer Science, The Scientific World Journal, Current Advances in 化学 Research, Cardiovascular regenerative medicine, Research Journal of Chemistry and Environment,Frontiers of Chemical Science and Engineering,纳米技术(NanoTechnology),Open Journal of Polymer Chemistry,Chinese Journal of Engineering,合成化学研究,中国组织工程研究等期刊编委,“中国科技论文在线”评审专家

个人履历

1989和1992年于南开大学获高分子专业本科和硕士学位。

1992年6月~1997年7月在天津大学化工学院工作,1997年获得天津大学有机化工工学博士,1997年8月作为教育部公派访问学者留学德国。

2000年10月获得亚琛工业大学理学博士学位,从事医用共分子材料研究。

2000-2001年在亚琛工业大学生物中心作博士后,

2001年10月-2003年9月德国ADIAM生命科学股份有限公司生物材料部主管,高分子家,2003年10月-2007年3月,德国GKSS研究中心高分子材料研究所和BCRT生物材料和再生治疗技术研究中心化学家,负责眼科材料和多功能性材料的研发工作。

2003年4月,天津大学化工学院教授。2008年入选教育部新世纪优秀人才。

讲授课程

高分子物理,生物材料与组织工程

研究领域(方向):

多功能高分子材料,医用高分子材料,药物缓释,

参加学术团体:

天津市化工学会委员,天津市生物医学工程学会委员,美国化学会会员,Research Journal of 化学 and Environment 海外编委

课题成果:

完成的项目:

1. 人工合成材料制作心脏瓣膜病研究开发,ADIAM 生命科学技术有限公司资助项目

2. 人工合成材料制作细径心血管研究开发,ADIAM 生命科学技术有限公司资助项目

3. 生物相容形状记忆材料,德国联邦教育研究部

4. 眼科材料和再生治疗的研究,德国联邦教育研究部

5. 生物材料研发和再生医学研究,德国联邦教育研究部

代表论文

曾在国内外刊物上发表论文40余篇,24篇被SCI检索,申请发明专利2项。有关的成果如下:

代表性论著:

研究论文

1. Armin Alteheld, Yakai Feng, Steffen Kelch, and Andreas Lendlein

Biodegradable Amorphous Copolyester-Urethane Networks Having Shape-Memory Properties

Angewandte Chemie International Edition 2005, 44, 1188-1192

2. Andreas Lendlein, Joerg Zotzmann,Yakai Feng, Armin Alteheld, Steffen Kelch

Controlling the switching 温度 of biodegradable, amorphous shape-memory poly(RAC交酯)urethane networks by incorporation of different Comono中东呼吸综合症, Biomacromolecules, 2009, 10 (4), 975–982

3. MARC Behl, Ute Ridder, Yakai Feng, Steffen Kelch, Andreas Lendlein, Shape-memory capability of binary multiblock copolymer blends with hard and switching domains provided by different components, Soft Matter, 2009, 5(3), 676-684

4. Yakai Feng, MARC Behl, Steffen Kelch, Andreas Lendlein

Biodegradable Multiblock Copolymers Based on Oligodepsipeptides with Shape-Memory Properties, Macromol. Biosci. 2009, 9(1), 45-54.

5. J. Zotzmann, M. Behl, Y. Feng, and A. Lendlein

Copolymer Networks Based on Poly(w-pentadecalactone) and Poly(e-caprolactone) Segments as a Versatile Triple-Shape Polymer System,Adv. Funct. Mater. 2010, 20(20), 3583–3594.

6. Yakai Feng, Shifeng Zhang, Li Zhang, Jintang Guo, and Yongshen Xu,Synthesis and Characterization of hydrophilic Polyester-PEO Networks with Shape-memory Properties, Polym. Adv. Technol. 2011, 22(12), 2430-2438

7. Yakai Feng, Jian Lu, Marc Behl, Andreas Lendlein, Degradable depsipeptide-based multiblock copolymers having polyester or polyetherester segments, The International Journal of Artificial Organs, 2011; 34(2): 103-109.

8. Yakai Feng, Haiyang Zhao, Licai Jiao, Jian Lu, Heyun Wang, Jintang Guo, Synthesis and Characterization of Biodegradable, Amorphous, Soft IPNs with Shape-memory Effect, Polymers for Advanced Technologies 2012, 23, 382-388

9. Heyun Wang, Yakai Feng, Bo An, Wencheng Zhang, Minglin Sun, Zichen Fang, Wenjie Yuan, Massuri Khan, Fabrication of PU/PEGMA crosslinked hybrid scaffolds by in situ UV photopolymerization favoring human endothelial cells growth for vascular tissue engineering, J Mater Sci: Mater Med, 2012.23(6):1499-1510

10. Yakai Feng, Haiyang Zhao, MARC Behl, Andreas Lendlein, Jintang Guo, and Dazhi Yang, Grafting of Poly(乙烯 glycol) Monoacrylates on Polycarbonateurethane by UV Initiated Polymerization for Improving Hemocompatibility, Journal of Materials Science-Materials in Medicine, 2013,24, 61-70.

11. Li Zhang, Yakai Feng, Hong Tian, Miao Zhao, Musammir Khan, Jintang Guo, Amphiphilic Depsipeptide-Based Block Copolymers as Nanocarriers for Controlled Release of 布洛芬 with Doxorubicin, J. Polym. Sci., Part A: Polym. Chem. 2013, 51(15), 3213–3226

12. Musammir Khan, Yakai Feng, Dazhi Yang, Wei Zhou, Hong Tian, Ying Han, Li Zhang, Wenjie Yuan, Jin Zhang, Jintang Guo, Wencheng Zhang, Biomimetic Design of Amphiphilic Polycations and surface Grafting onto Polycarbonate Urethane Film as Effective Antibacterial Agents with Controlled Hemocompatibility, J. Polym. Sci., Part A: Polym. Chem. 2013, 51(15), 3166–3176

13. Wenjie Yuan, Yakai Feng, Heyun Wang, Dazhi Yang, Bo An, Wencheng Zhang, Musammir Khan, Jintang Guo, Hemocompatible surface of electrospun nanofibrous scaffolds by ATRP modification,Materials Science and Engineering C 2013, 33(7), 3644-3651

14. Li Zhang, Yakai Feng, Juan Lv, Jing Yang, Hong Tian, Changcan Shi, Miao Zhao, Jintang Guo, Controlled release of doxorubicin from amphiphilic depsipeptide-PDO-PEG-based copolymer nanosized microspheres, Reactive \u0026 Functional Polymers, 2013,73(9), 1281–1289.

15. Cangcan Shi, Fanglian Yao, Jiawen Huang, Guoliang Han, Qian Li, Musammir Khan, Yakai Feng, Wencheng Zhang, Proliferation and Migration of Human Vascular Endothelial Cells Mediated by ZNF580 Gene Complexed with mPEG-b-P(MMD-co-GA)-g-PEI Microparticles, Journal of materials 化学 B, Materials for biology and medicine. 2014, 2(13), 1825-1837

16. Changcan Shi, Fanglian Yao, Jiawen Huang, Qian Li, Musammir Khan, Yakai Feng, Wencheng Zhang, Regulation of the Endothelialization by Human Vascular Endothelial Cells by ZNF580 Gene Complexed with Biodegradable Microparticles, Biomaterials, 2014, 35, 7133-7145

17. Miao Zhao, Yakai Feng, Guang Li, Yuan Li,Yalong Wang, Ying Han, Xujun Sun, Xiaohua Tan, Synthesis of An Adhesion-enhancing Polysiloxane Containing Epoxy Groups for Addition-cure Silicone Light Emitting Diodes (LEDs) Encapsulant, Polymers for Advanced Technologies, 2014, 25, 927-933.

18. Miao Zhao, Yakai Feng, Yuan Li, Guang Li, Yalong Wang, Ying Han, Xujun Sun, Xiaohua Tan, Fabrication of 硅氧烷 Hybrid Material with High Adhesion and High Refractive Index for Light Emitting Diodes (LEDs) Encapsulation,51(8): 653-658.

19. Miao Zhao, Yakai Feng, Yuan Li, Guang Li, Yalong Wang, Ying Han, Xujun Sun, Xiaohua Tan, Preparation and 表演 of Phenyl-Vinyl-POSS/Addition-type Curable Silicone Rubber Hybrid Material, Journal of Macromolecular Science, Part A: Pure and Applied 化学, 2014, 51(8): 639-645.

20. Li Zhang, Yakai Feng, Bibliometrics and visualization analysis of artificial blood vessel research, Current Science, 2014, 106(6), 816-822.

21. Li Yu, Xuefang Hao, Qian Li, Changcan Shi, Yakai Feng, Electrospun PLGA/SF modified with electrosprayed microparticles: a novel biomimetic composite scaffold for vascular tissue engineering, Adv. Mater. Res. 2014, 1015, 336-339.

22. Juan Lv, Li Zhang, Musammir Khan, Xiangkui Ren, Jintang Guo, Yakai Feng, Biodegradable depsipeptide-PDO-PEG-based block copolymer micelles as nanocarriers for controlled release of doxorubicin, Reactive and Functional Polymers, 2014, 82, 89-97.

23. 于丽,冯亚凯,石常灿,郝雪芳,吗啉2,5-二酮衍生物及其聚合物的研究进展, 高分子通报, 2015,3:18~25.

24. 周伟,冯亚凯, 静电纺丝SF/PLGA纤维支架用于血管组织工程的研究, 化学工业与工程

25. Musammir Khan, Jing Yang, Changcan Shi, Yakai Feng,* Wencheng Zhang, Katie Gibney, Gregory N. Tew, Manipulation of polycarbonate urethane bulk properties via incorporated zwitterionic polynorbornene for tissue engineering application,RSC Advances, 2015, 5, 11284-11292.

26. Wei Zhou, Yakai Feng*, Jing Yang, Jiaxu Fan1, Juan Lv , Li Zhang, Jintang Guo, Xiangkui Ren*, WenchengZhang, Electrospun membranes of silk fibroin and poly(交酯co-glycolide) as potential nonthrombogenic scaffolds for vascular tissue engineering application, Journal of Materials Science: Materials in Medicine. DOI 10.1007/s10856-015-5386-6

27. Changcan Shi, Fanglian, Yao, Wenjie Yuan, Musammir Khan, Qian Li, Yakai Feng,* Wencheng Zhang, Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation, Material Science and Engineering C 50 (2015) 201–209.

28.Qian Li, Changcan Shi, Jiawen Huang, Jing Yang, Yakai Feng*, Wencheng Zhang, Marc Behl, and Andreas Lendlein, Self-assembly Complexed Gene Nanoparticles to Promote the Proliferation of Human Vascular Endothelial Cells, Advanced Healthcare Materials, DOI: 10.1002/adhm.201400817

29. Haixia Wang, Yakai Feng*, Jing Yang, Jintang Guo* and Wencheng Zhang*, Targeting REDV peptide functionalized polycationic gene carrier for enhancing the transfection and migration capability of human endothelial cells. Journal of Materials Chemistry B 2015,3, 3379-3391

30. Li Yu, Yakai Feng*, Qian Li, Xuefang Hao, Wen Liu, Wei Zhou, Changcan Shi, Xiangkui Ren*, Wencheng Zhang*, PLGA/SF blend scaffolds modified with plasmid complexes for enhancing proliferation of endothelial cells. Reactive and Functional Polymers, 2015, 91-92, 19–27

31. Musammir Khan, Jing Yang, Changcan Shi, Yakai Feng*, Wencheng Zhang, Katie Gibney, Gregory N. Tew*, surface Modification of Polycarbonate Urethane with Zwitterionic Polynorbornene via 硫醇ene Click-Reaction to Facilitate Cell Growth and Proliferation, Macromolecular Materials and Engineering, DOI:10.1002/mame.201500038

32. Musammir Khan, Jing Yang, Changcan Shi, Juan Lv, Yakai Feng *, Wencheng Zhang *, surface tailoring for selective endothelialization and platelet inhibition via a combination of SI-ATRP and Click-化学 using Cys-Ala-Gly-peptide, Acta Biomaterialia, 2015, 20, 6981

33. Xiangkui Ren, Yakai Feng*, Jintang Guo, Haixia Wang, Qian Li, Jing Yang, Xuefang Hao, Juan Lv, Nan Ma*, Wenzhong Li, surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering application, Chemical Society Reviews,已接收

34. Xuefang Hao#, Qian Li #, Juan L, Li Yu, Xiangkui Ren, Li Zhang, Yakai Feng*, Wencheng Zhang*, CRED大众卡车linked polymeric micelles as a targeting gene transfer vector for selective transfection and proliferation of endothelial cells, ACS Appl. Mater. Interfaces, 已接收

获得专利

Yakai Feng, Steffen Kelch, Andreas lendlein

Multiblockcopolymere mit Formgedächtniseigenschaften

2006, Nr. 10 2006 023365.4

参考资料