张静
张静 博士,福建农林大学生命科学学院化学生物学系,副教授,硕士生导师。入选“福建省高等学校新世纪优秀人才支持计划”、“福建省高校杰出青年科研人才计划”、“福建省卫生系统学术技术带头人后备人才”、福建农林大学“金山学者”拔尖人才和学术新秀、“福建农林大学杰出青年科技人才培养”计划。主要从事纳米电化学、光学可视化生物传感技术和电致化学发光生物传感技术及其在真菌毒素、肿瘤相关基因、蛋白和金属离子检测方面的研究。已成功设计了短直链型、发卡型、“Y”型交联、G-四倍体型、锁核酸等各类核酸探针,并将其与核酸适配体、脱氧核糖核酸自组装、纳米金属簇、DNA模拟酶和目标序列诱导循环信号放大等技术相结合,开发了多种高灵敏、高特异性的纳米生物传感器。先后主持国家自然科学基金、福建省自然科学基金、福建省医学创新基金等多项科研项目。发表SCI论文二十多篇,累计被引用800多次,第一作者或第一通讯作者的SCI总影响因子达92,单篇影响因子大于5.0的有11 篇。一区的8篇。获“福建省优秀博士论文学位论文三等奖”、 “福建省自然科学优秀学术论文三等奖”、“福建农林大学严家显最高奖教金”、“福建省技术发明奖”(排名第四)。
教育经历
1997年9月-2001年7月,山西大学,应用化学系,学士。
2001年9月-2004年7月,福州大学,化学化工学院分析化学专业,硕士。导师:庄惠生。研究方向为NP的分析检测。
2007年9月-2011年7月,福州大学,化学化工学院分析化学专业,博士,导师:付凤富。研究方向为电化学生物传感器。
工作经历
2004年8月-2011年10月,福建卫生职业技术学院,药学系,讲师。
2011年10月至今,福建农林大学,生命科学学院,副教授,硕士生导师。
科研项目
1、基于无酶循环放大策略的多通道纳米电化学生物传感器用于肝癌多元肿瘤标志物的联合检测(21205015),国家自然科学基金,2013.1- 2015.12。
2、基于脱氧核糖核酸自组装和DNA模拟酶技术的多通道电化学适体传感器用于农产品中多种真菌毒素的协同检测(JA13088),福建省高等学校新世纪优秀人才支持计划,2014.1- 2016.12。
3、超灵敏非标记型电化学生物传感器用于唾液中乳腺癌相关基因的非创伤性检测(2011J01028),福建省自然科学基金, 2011.4-2014.3。
4、用于唾液快速检测乳腺癌的生物传感器的研制(2011-CX-22),福建省医学创新基金,2011.9-2014.9,主持人。
5、拉链核酸探针纳米电化学生物传感器测定转基因植物特定序列的研究(JA10295),福建省高校杰出青年科研人才计划,2010.3-2013.3。
6、用于快速检测肝癌相关蛋白的核酸适配体生物传感器的研制(2010126),福建省卫生厅青年基金,2010.3-2013.3。
主要作品
论文
1.Jing Zhang*,Meifeng Hou,Guanyu Chen,Huifang Mao,Wenqian Chen,Wenshen Wanga,Jing-Hua Chen,An electrochemical biosensor based on 脱氧核糖核酸 “nano-bridge” for amplified detection of exosomal microRNAs,Chinese Chemical Letters 2021,32,11,3474-3478
2.Jing Zhang,Liang-Liang Wang,Mei-Feng Hou,Li-Pei Luo,Yi-Juan Liao,Yao-Kun Xia,An Yan,YunPing Weng,Lu-Peng Zeng,Jing-Hua Chen*,Label-free fluorescent and electrochemical biosensors based on defective G-quadruplexes.Biosensors and Bioelectronics,2018,118,1-8.(Ⅰ区,IF:7.78)
3.Jing Zhang,Liang-Liang Wang,Mei-Feng Hou,Yao-Kun Xia,Wen-Hui He,An Yan,Yun-Ping Weng,Lu-Peng Zeng,Jing-Hua Chen*,A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal 脱氧核糖核酸 walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction,Biosensors and Bioelectronics,2018,102,33-40.(Ⅰ区,IF:7.78)
4.Jing Zhang,越南盾Zhi Wu,Shu-Xian Cai,Mei Chen,Yao-Kun Xia,Fang Wu,Jing-Hua Chen*,An immobilization-free electrochemical impedance biosensor based on duplex-specific nuclease assisted target recycling for amplified detection of microRNA,Biosensors and Bioelectronics,2016,75,452-457.(Ⅰ区,IF:6.409)
5.Jing Zhang,Yao-Kun Xia,Mei Chen,越南盾Zhi Wu,Shu-Xian Cai,Meng-Meng Liu,Wen-Hui He,Jing-Hua Chen*,A Fluorescent Aptasensor based on 脱氧核糖核酸scaffolded Silver Nanoclusters Coupling with Zn(Ⅱ)-ion Signal-enhancement for Simultaneous Detection of OTA and AFB1,Sensors and Actuators B,2016,235,79-85.(Ⅰ区,IF:4.097)
6.Jing Zhang,Dongzhi Wu,QiuXiang Chen,Mei Chen,Yaokun Xia,Shuxian Cai,Xi Zhang,Fang Wu,Jinghua Chen*,Label-Free MicroRNA Detection based on Terbium and Duplex-Specific Nuclease Assisted Target Recycling.Analyst,2015,140,5082-5089.(Ⅱ区,IF:4.107)
7.Shuxian Cai,Guangwen Li,Xi Zhang,Yaokun Xia,Mei Chen,Dongzhi WuQiuxiang Chen,Jing Zhang*,Jinghua Chen*,A signal-on fluorescent aptasensor based on single-stranded 脱氧核糖核酸sensitized luminescence of terbium (III) for label-free detection of breast cancer cells.Talanta,2015,138,225-230.(Ⅱ区,IF:3.545)
8.Xi Zhang,Dongzhi Wu,Zhijing Liu,Shuxian Cai,Yanping Zhao,Mei Chen,Yaokun Xia,Chunyan Li,Jing Zhang* and Jinghua Chen*,An ultrasensitive Label-Free Electrochemical Biosensor for MicroRNA-21 Detection based on 2’-O-甲基 modified DNAzyme and Duplex-Specific Nuclease Assisted Target Recycling.Chemical Communications,2014,50,12375-12377.(Ⅱ区,IF:6.834)
9.Xi Zhang,Jing Zhang*,Dongzhi Wu,Zhijing Liu,Shuxian Cai,Mei Chen,Yanping Zhao,Chunyan Li,Huanghao Yang*,Jinghua Chen*,Ultraselective Electrochemiluminescence Biosensor Based on Locked Nucleic Acid Modified Toehold-Mediated Strand Displacement Reaction and Junction-probe,Analyst,2014,139,6109-6112.(Ⅱ区,IF:4.107)
10.Jinghua Chen,Xi Zhang,Shuxian Cai,Dongzhi Wu,Mei Chen,Shihua Wang*,Jing Zhang*,A Fluorescent Aptasensor based on 脱氧核糖核酸Scaffolded Silver-Nanocluster for Ochratoxin A Detection,Biosensors and Bioelectronics,2014,57,226-231.(Ⅰ区,IF:6.409)
11.Jinghua Chen,Jia Lin,Xi Zhang,Shuxian Cai,Dongzhi Wu,Chunyan Li,Sheng Yang*,Jing Zhang*,Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short 脱氧核糖核酸 物种 of c-erbB-2 detection,Anal Chim Acta.2014,817,42-47.(Ⅱ区,IF:4.513)
12.Jinghua Chen*,Xi Zhang,Shuxian Cai,Dongzhi Wu,Jia Lin,Chunyan Li,Jing Zhang*,Label-free electrochemical biosensor using home-made 10-甲基3-nitro-acridone as indicator for picomolar detection of nuclear factor kappaB,Biosensors and Bioelectronics,2014,53,12-17.(Ⅰ区,IF:6.409)
13.Jing Zhang,XiaoYan Wu,WeiJuan Yang,JingHua Chen*,FengFu Fu*,Ultra-sensitive electrochemical detection of single nucleotide polymorphisms based on an electrically controllable magnetic gold electrode,Chem.Commun.2013,49,10,996-998.(Ⅱ区,IF:6.834)
14.Jing Zhang,Xi Zhang,Guidi Yang,Jinghua Chen*,Shihua Wang,A signal-on fluorescent aptasensor based on Tb(3+) and structure-switching aptamer for label-free detection of Ochratoxin,Biosensors \u0026Bio电子学2013,15,41,704-709.(Ⅰ区,IF:6.409)
15.Jing Zhang,Jinghua Chen*,Xi Zhang,Zhigao Zeng,Mei Chen,Shihua Wang,An electrochemical biosensor based on hair松属脱氧核糖核酸 aptamer probe and restrictionendonuclease for ochratoxin A detection,Electrochemistry Communications.2012,25(25): 5-7.(Ⅱ区,IF:4.859)
16.Jing Zhang,Pingping Chen,XiaoYan Wu,JingHua Chen*,LiangJun Xu,GuoNan Chen,FengFu Fu,A signal-on electrochemiluminescence aptamer biosensor for the detection of ultratrace thrombin based on junction-probe.Biosensors and Bioelectronics,2011,26(5): 2645-2650.(Ⅰ区,IF:6.409)
17.Jing Zhang,QingLan Gao,PingPing Chen,JingHua Chen*,GuoNan Chen,FengFu Fu.A novel Tb3+-promoted G-quadruplex-氯化血红素 DNAzyme for the development of label-free visual biosensors.Biosensors and Bioelectronics,2011,26(10): 4053-4057.(Ⅰ区,IF:6.409)
18.Jing Zhang,XiaoYan Wu,PingPing Chen,NingTing Lin,JingHua Chen*,GuoNan Chen,FengFu Fu.Electrochemical genotyping and detection of single-nucleotide polymorphisms based on junction-probe containing 2'-deoxyinosine.Chem.Commun.,2010,46(37):6986-6988.(Ⅱ区,IF:6.834)
19.Jing Zhang,Jing Hua Chen,Rong Chun Chen,Guo Nan Chen,Feng Fu Fu*.Sequence-specific detection of trace 脱氧核糖核酸 via a junction-probe electrochemical sensor employed template-enhanced hybridization strategy.Biosensors and Bioelectronics,2009,25(4): 815-819.(Ⅰ区,IF:6.409)
20.Jing Zhang,Jing Hua Chen,Rong Chun Chen,Guo Nan Chen,Feng Fu Fu*.Biosensors and Bioelectronics,2009,25(2):378-382.(Ⅰ区,IF:6.409)
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荣誉
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参考资料
张静.福建农林大学.2018-12-28
张静.福建农林大学生命科学学院.2024-09-09