简单百科
洪学传

洪学传

洪学传，汉族，是一名教授，任职于武汉大学药学院。他毕业于天津大学，并担任楚天学者特聘教授。截至2019年7月，他已发表13篇论文。

学习简历

1993.9 - 1997.7 天津大学攻读应用化学系精细化工专业学士

1993.9 - 1997.7 天津大学攻读管理学院技术经济学士双学位

1997.9 - 1999.11 天津大学免试攻读化工学院应用化学专业硕士学位

1999.12 -2000.7 北海道大学药学院和触媒化学研究中心研修生

2001.1 - 2005.7 美国密苏里大学哥伦比亚分校攻读有机化学博士学位

工作简历

1997.9 - 1999.11 天津大学化工学院97级本科生辅导员

1999.12–2000.07 日本北海道大学，药学院，研修生

2005.9 - 2007.9美国爱默里大学博士后研究员

2007.10- 2010. 10AMRI, Albany, NY, USA 资深科学家

2010.10- 2011.4武汉大学药学院, 教授

2011.5-至今武汉大学药学院, 楚天学者特聘教授，武汉大学药学院邓子新院士创新团队成员。

2017.12 – 至今西藏大学医学院教授，博士生导师

业绩概要

1)国内国际核心化学期刊上发表论文37篇及英文专著一章。

2)率先发现了以手性亚亚胺(sulfoximine)为手性助剂的不对称的1,4-加成反应, 使在芳香基团, 杂环化合物共扼环的α位引入手性烷基手性中心更加容易。反应具有广泛的普遍性和绝对的立体选择性。

3)在美国国立卫生研究院(NIH), 结核病 Antimicrobial Acquisition and Coordinating Facility (TAACF) 和 CV Therapeutics 的支持下, 利用这特定的化学设计, 合成了一系列具有绝对构像的抗结核病的天然或非天然化合物例如(+)-curcumeme, (+)-curcuphenol, pesudoteroxazole, erogorgiaene, colombiasin A 和 elisapterosin B及分子改造, 开发出了一些选择性地高, 毒性小的抗结核剂。

4)发现用改进的aza-Achmatowicz 方法合成多取代吡咯。确定(II)催化吲环加成串联反应的相对立体构像。设计, 合成了一系列具有高生物活性的天然化合物例如kopsifoline的核心结构。

5)曾从事各类癌症药物和肥胖症的小分子药物等发现，合成, 研制及工业开发。其中一个临床III药在2009年9月得到美国FDA批准。

获奖情况

2004Breckenridge Lyons Award for Outstanding Graduate Research, University of Missouri-Colombia

2004Gordon Research Conference on Organic Reactions and Process Chair Award.

2014年获武汉市第三批“黄鹤英才”人才计划。

2014年获美国化学会组织颁发的第九届世界华人药学会最佳报告奖。

2015年获武汉大学医学部医学突出贡献奖。

2016年武汉大学珞珈学者特聘教授，武汉大学医学部医学突出贡献奖，武汉大学朱裕璧医学奖。

研究领域

药物化学，有机化学，分子影像(Molecular Imaging)

研究兴趣与方向

1.活性天然产物的全合成

2.化学合成药物的开发与研究

3.运用现代生物学技术进行药物开发

4.用于肿瘤光声成像的分子探针的研制和开发

已发表的学术论文

著作：

1.“Recent Progress in the 化学 of 2,1-Benzothiazines”

Xuechuan hong; Michael Harmata. Progress in Hetereocyclic Chemistry, Chapter 1, G. W. Gribble and J. A. joule, eds, Pergamon Press, Vol 20, pp 1–43 (2008)

发表论文：

1．“Metal-free direct amidation of peptidyl 硫醇 esters with -amino acid esters.” Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong* and Zixin Deng, Green Chem., 2011, 13“The Intramolecular, Stereoselective Addition of Sulfoximine Carbanions to α,β-unsaturated Esters.”Michael Harmata; Xuechuan Hong. J. Am. Chem.l Soc.2003, 125(19), 5754–5756. , 2723

3. “Asymmetric Organocatalysis of [4+3] Cycloaddition Reactions.” Michael Harmata; Sunil K. Ghosh; Xuechuan Hong; Sumrit Wacharasindhu; Patrick Kirchhoe铁 J. Am. Chem.l Soc. 2003, 125(8), 2058–2059.

4. “A Cycloaddition Protocol for the Assembly of the Heterocyclic Framework Associated with the Kopsifoline alkaloids.”Xuechuan Hong; Stefan France; José M. Mejía-Oneto; Albert Padwa. Org. Lett. 2006, 8, 5141–5144.

5. “Benzothiazines in Synthesis. A Total Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong. Org. Lett. 2005, 7(16), 3581–3583.

6.“Benzothiazines in Synthesis. Toward the Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong; Charles L. Barnes. Org. Lett.2004, 6(13), 2201–2203.

7."Benzothiazines in Organic Synthesis.The Preparation of Enantiomerically Pure 4-Substituted Quinolones” Michael Harmata; Xuechuan Hong. Org. Lett. 2007, 9, 2901–2904.

8.“Benzothiazines in Synthesis. Stereoselective Synthesis of Erogorgiaene.”Michael Harmata; Xuechuan Hong;Peter R. Schreiner. J. Org. Chem.2008, 73, 1290–1296.

9. “Synthesis of 2,4-Disubstituted Pyrroles by Rearrangements of 2-Furanyl Carbamates.”Sezgin Kiren; Xuechuan Hong; Carolyn A. Leverett; Albert Padwa.Org. Lett. 2009, 11(6), 1233–1235.

10. “A dipolar Cycloaddition Approach Toward the Kopsifoline Alkaloid Framework.” Xuechuan Hong; Stefan France; Albert Padwa. Tetrahedron, 2007, 63, 5962–5976.

11. “铑 Carbenoid Induced Cycloadditions of Diazo Ketoamides across Indolyl π-Bonds.”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Synlett, 2007, 775–779.

12. “Lewis Acid Promoted a-Hydroxy b-Dicarbonyl to a-Ketol Ester Rearrangement.” Xuechuan Hongıa-Oneto; Albert Padwa. Tetrahedron Lett. 2006, 47, 8387–8390.;Jose M. Mej

13. “Photodesulfonylation of Indoles Initiated by Electron Transfer from 三乙胺”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Tetrahedron Lett.2006, 47, 2409–2412.

14. “钯catalyzed Cross-coupling Reactions of a Sulfoximine with Aryl Dichlorides under 微波 Irradiation.”Michael Harmata; Xuechuan Hong. Synlett, 2007, 969–973.

国际学术会议报告

1. “Studies of the 化学 of 2,1-Benzothiazines and an Approach to the Synthesis of Antitubercular Natural Products.” Xuechuan Hong*nd International Symposium on Organic Synthesis and Drug Development,Nanjing, China, October 14-16, 2010.. Presented at 2

2. “Benzothiazines in Synthesis. Synthesis of Enantiomerically Pure 3,4-Dihydroquinolin-2(1H)-ones.” Michael Harmata; Xuechuan Hong*. ORGN-029l presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.

3. "Benzothiazines in Synthesis. A Route to Chiral Cyclobutanes” Michael Harmata; Weijiang Ying and Xuechuan Hong. ORGN-515 presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.

4.“Benzothiazines in Synthesis. Stereoselective Synthesis of Diastereomers of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. ORGN-060 presented present at the 228 National Meeting of the American Chemical Society, 费城, August 22-26, 2004.

5. “微波assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. ORGN-165 presented at the 228 National Meeting of the American Chemical Society, 费城, August 22-26, 2004.

6. “Towards a Synthesis of Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.

7. “微波assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.

8.“Benzothiazines in Synthesis. Towards Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. ORGN-061 presented at the 228National Meeting of the American Chemical Society, 费城, August 22-26, 2004.

9. “Towards a Synthesis of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. Paper #48 presented at the 38 Annual Midwest Regional Meeting of the American Chemical Society, Colombia, November 5-7, 2003。

参考资料

洪学传.武汉大学药学院.2021-12-18

洪学传教授团队.发育源性疾病湖北省重点实验室.2021-12-18