杨竞

杨竞，男，2015年入职北京大学生命科学学院助理教授，并受聘北京大学清华生命科学联合中心和IDG麦戈文脑科学研究所研究员。他的研究领域主要集中在神经科学，特别是神经退行性疾病和代谢调控机制等前沿领域的基础和应用研究。杨竞教授已在《细胞》(细胞)、《神经元》(Neuron)等国际著名学术期刊上发表论文十余篇，并在2015年获得国家中华人民共和国国家自然科学基金委员会“优秀青年科学基金”。

个人经历

杨竞教授于2003年在赵进东院士的指导下，于北京大学生命科学学院获得生物科学学士。随后，他在美国得克萨斯大学西南医学中心师从诺贝尔奖得主Michael Brown和Joseph Goldstein，于2009年获得生物医学博士学位。在获得博士学位后，杨竞教授在美国基因泰克公司和洛克菲勒大学从事博士后研究，直至2015年加入北京大学生命科学学院。在学术成就方面，杨竞教授曾获得Tri-Institutional Breakout Prize、“求是”杰出青年学者奖等多项学术奖项。

研究领域

杨竞教授的研究领域涉及神经科学，特别是神经退行性疾病和代谢调控机制。他的工作揭示了神经系统和免疫系统之间密不可分的联系，特别是在神经系统调节多种器官和组织内免疫反应的重要功能方面。这一领域的研究为生物医学研究提供了新的视角，并为治疗不同免疫相关疾病提供了潜在的治疗策略。

学术成就

杨竞教授在神经生物学领域的研究成果获得了广泛认可。他在2016年获得“求是杰出青年学者奖”，该奖项是通过求是基金会严格的同行评议和专家委员会评审后授予的。此外，他还曾获得国家中华人民共和国国家自然科学基金委员会“优秀青年科学基金”以及其他学术奖项，以表彰他在科研领域的卓越贡献。

主要论文

Publications since the current position:

1. Representative Publications (# corresponding author):

(1) Xu Q, Cao Y, Kong F, Liu J, Chen X, Zhao Y, Lai CH, Zhou X, Hu H, Fu W, Chen J, Yang J#. 倍数 Cancer 细胞 Types Release LIF and Gal3 to Hijack Neural Signals. Cell Research. 2024 May;34(5):345-354.

(2) Gong X, Chong K, Liu J, 成姓 W, Yang J#, Liu B#. AIENP-Reinforced 迪斯科 Method for Whole-Tissue Three-Dimensional Reconstruction of Pulmonary Capillaries. Advanced Functional Materials. 2024 Mar;34(13):2312176.

(3) Zhang M, Liu T, Yang J#. Skin neuropathy and immunomodulation in diseases. Fundamental Research. 2024 Mar;4(2):218-225.

(4) Liu J, Li Z, Li M, Du W, Baumeister W, Yang J#, Guo Q#. Vimentin regulates NU.CLEAR segmentation in neutrophils. Proceedings of the National Academy of Sciences of the United States of America. 2023 Nov 28;120(48):e2307389120.

(5) Liu T, Liu J, Chen H, Zhou X, Fu W, Cao Y, Yang J#. Cannabinoid 捕手 2 signal promotes type 2 immunity in the lung. 细胞 Insight. 2023 Oct 6;2(5):100124.

(6) Cao Y, Chen H, Yang J#. Neuroanatomy of lymphoid organs: Lessons learned from whole‐tissue imaging studies. European Journal of Immunology. 2023 Oct;53(10):e2250136.

(7) Cao Y, Liu T, Zhou X, Fu W, Li J, Yang J#. 3D anatomy of autonomic innervations in immune organs of a non-human 灵长目 and the human. Fundamental Research. 2023 Mar;3(2):249-256.

(8) Yang J#, Yaron A, Liu K. Editorial: Neuroimmune interactions in peripheral neuropathy. Frontiers in Molecular 神经科学 2022 May;15:929081.

(9) Liu C, Yang J#. Enteric glial cells in immunological disorders of the gut. Frontiers in Cellular Neuroscience. 2022 Apr;16:895871.

(10) Cao Y, Wang Y, Yang J#. NAD+-dependent mechanism of pathological axon degeneration. 细胞 Insight. 2022 Mar 4;1(2):100019.

(11) Sun Y, Wang Q, Wang Y, Ren W, Cao Y, Li J, Zhou X, Fu W, Yang J#. Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon. Protein 细胞 2021 Aug;12(8):621-638.

(12) Liu K, Yang L, Wang G, Liu J, Zhao X, Wang Y, Li J, Yang J#. Metabolic 应力 drives sympathetic neuropathy within the liver. Cell 新陈代谢 2021 Mar 2;33(3):666-675.e4.

(13) Jiang Y, Liu T, Lee CH, Chang Q, Yang J#, Zhang Z#. The NAD(+)-mediated self-inhibition mechanism of proneurodegenerative SARM1. Nature. 2020 Dec;588(7839):658-663.

(14) Liu T, Yang L, Han X, Ding X, Li J, Yang J#. Local sympathetic innervations modulate the lung innate immune responses. Science Advances. 2020 May 13;6(20):eaay1497.

(15) Wang Q, Liu K, Yang L, Wang H, Yang J#. BoneClear: whole-tissue immunolabeling of the intact mouse bones for 3D imaging of neural anatomy and pathology. Cell Research. 2019 Oct;29(10):870-872.

(16) Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, Wang Q, Yang J#. 复总状花序Shaped Sympathetic 建筑 in the Spleen Parenchyma Modulates Antibacterial Innate Immunity. Cell Reports. 2019 Jun 25;27(13):3799-3807.e3.

(17) Zhou N, Liu K, Sun Y, Cao Y, Yang J#. Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition. Protein 细胞 2019 Feb;10(2):87-103.

(18) Zhou N, Yang J#. Molecular Mechanism of Wallerian Degeneration. Chinese Bulletin of Life Sciences. 2017 Mar; 29(3): 245-250.

2. Additional Publications:

(1) Liu T, Wang H, Kutsovsky DY, Iskols M, Chen H, Ohn CYJ, Patel N, Yang J, Simon DJ. An axon-T 细胞 feedback loop enhances inflammation and axon degeneration. Cell Reports. 2024 Feb 27;43(2):113721.

(2) Yang L, Wang X, Yu XX, Yang L, Zhou BC, Yang J, Xu 铬 The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms. Developmental 细胞 2023 Sep 25;58(18):1688-1700.e6.

(3) Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z. Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell 探索频道 2022 Dec 28;8(1):141.

(4) Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z. Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8. Nature Communications. 2022 Aug 25;13(1):4988.

(5) Hu H, Cui YW, Yang J, Cao Y. Loss of the sympathetic signal produces sterile inflammation of the prostate. Frontiers in Molecular 神经科学 2022 May;15:855376.

(6) Li X, Qi L, Yang D, Hao S, Zhang F, Zhu X, Sun Y, Chen C, Ye J, Yang J, Zhao L, Altmann DM, Cao S, Wang H, Wei B. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nature 神经科学 2022 May;25(5):577-587.

(7) Qian K, Liu J, Cao Y, Yang J, 裘姓 S. Intraperitoneal injection of 锂 氯代十六烷 induces lateralized activation of the insular cortex in adult mice. Molecular Brain. 2021 Apr 19;14(1):71.

(8) Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. A growth-factor-activated lysosomal K(+) channel regulates Parkinson`s 病理学 Nature. 2021 Mar;591(7850):431-437.

(9) Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y. Mutation in ε-Sarcoglycan Induces a Myoclonus-肌张力障碍 综合征Like Movement Disorder in 鼠科 神经科学 Bulletin. 2021 Mar;37(3):311-322.

(10) Simon DJ, Pitts J, 赫兹 NT, Yang J, Yamagishi Y, Olsen O, Tešić Mark M, Molina H, Tessier-Lavigne M. Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling. 细胞 2016 Feb 25;164(5):1031-45.

3. Book Chapters:

(1) Cao Y, Yang J. Mechanisms of Pathological Axonal Degeneration. In: Tran SS501 and Yaron A.(eds) Wiring the Nervous System, 2024 Jan;215-250. River Publishers, Gistrup, Denmark.

(2) Cao Y, Yang J. Whole-Tissue Immunolabeling and 3D 荧光 Imaging to Visualize Axon Degeneration in the Intact, Unsectioned Mouse Tissues. In: Babetto E.(eds) Methods in Molecular Biology, 2020 Jun 11;2143:223-232. Humana, New York, NY.

(3) Wang F, Yang J, He Z. Axon maintenance and degeneration. In: Rubenstein J., Rakic P., Chen B., Kwan K.Y., Kolodkin A., and Anton E.(eds) Comprehensive Developmental 神经科学 (2nd Edition), 2020 Jun 5;217-230. Academic Press, Cambridge, MA.

Publications before the current position:

(1) Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal 死亡 through a MAPK cascade that triggers a local 能量 deficit. 细胞 2015 Jan 15;160(1-2):161-76.

(2) Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910.

(3) Yang J*, Weimer RM*, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, Tessier-Lavigne M. Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Dec 4;80(5):1175-89. (* contributed equally)

(4) Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 5;110(10):4039-44.

(5) Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O`Leary DD, Hannoush RN, Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. Journal of 神经科学 2012 Dec 5;32(49):17540-53.

(6) Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, Freeman MR. dSarm/Sarm1 is required for activation of an injury-induced axon 死亡 pathway. Science. 2012 Jul 27;337(6093):481-4.

(7) Sakata I*, Yang J*, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman Jackie McLean Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. American Journal of Physiology-Endocrinology and 新陈代谢 2009 Jul;297(1):E134-41. (* contributed equally)

(8) Yang J*, Zhao TJ*, Goldstein JL, Brown MS. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 5;105(31):10750-5. (* contributed equally)

(9) Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. 细胞 2008 Feb 8;132(3):387-96.

(10) Yang J, Dong C, Huang X, Zhao J. Sulfonation of polyvinylidene difluoride resin and its application in extraction of restriction enzymes from 脱氧核糖核酸 digestion solutions. Analytical Biochemistry. 2003 Nov 1;322(1):99-103.

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参考资料

杨竞.北京大学生命科学学院.2024-09-09